CAR-T cell therapy

Exploring CAR-T Cell Therapy at Zion Medic

Introduction: CAR-T cell therapy represents a beacon of hope for individuals battling refractory or relapsed hematologic malignancies, offering a revolutionary approach to cancer treatment. At Zion Medic, we’re dedicated to providing advanced oncological care, including CAR-T cell therapy, to empower our patients with renewed possibilities for remission and improved quality of life.

Understanding CAR-T Cell Therapy

CAR-T cell therapy, or Chimeric Antigen Receptor T-cell therapy, is a groundbreaking immunotherapy that reprograms a patient’s own immune cells to target and destroy cancer cells. This transformative approach begins with the extraction of T cells from the patient, followed by genetic engineering in a laboratory to express chimeric antigen receptors (CARs) on their surface. Once infused back into the patient, these CAR-T cells harness the power of the immune system to seek out and eliminate cancer cells with precision.

Benefits of CAR-T Cell Therapy:

Remarkable efficacy in achieving high response rates and durable remissions in certain types of blood cancers, including acute lymphoblastic leukemia (ALL), non-Hodgkin lymphoma (NHL), and chronic lymphocytic leukemia (CLL) Targeted and precise treatment that spares healthy tissues, minimizing side effects and enhancing treatment tolerability Potential as a bridge to curative therapies, such as bone marrow transplantation, for eligible patients Expanding Treatment Options: In addition to the aforementioned hematologic malignancies, CAR-T cell therapy holds promise for treating other cancers.

Which types of cancer can be treated with CAR-T therapy?

Acute Lymphoblastic Leukemia (ALL): Acute Lymphoblastic Leukemia (ALL) is a rapidly developing cancer of the blood and bone marrow, known for its aggressiveness and prevalence in both children and adults. Each year in the United States, approximately 1,000 new cases of ALL are diagnosed in adults alone. This disease is characterized by an overproduction of immature white blood cells called lymphoblasts, which hinder the normal production of healthy blood cells like red blood cells and platelets.

Acute Myeloid Leukemia (AML): Acute Myeloid Leukemia (AML) is another swiftly progressing form of leukemia that affects individuals of all ages, with a higher incidence in older adults, typically over the age of 65. AML originates in the bone marrow, where immature white blood cells known as myeloblasts are produced. Instead of maturing into functional blood cells, these myeloblasts rapidly proliferate, crowding out healthy blood cells and potentially spreading to other organs. If left untreated, AML can pose life-threatening risks. It’s noteworthy that Sheba Medical Center is leading a groundbreaking clinical study offering CAR-T therapy to AML patients with specific genetic translocations, such as t(8;21).

Non-Hodgkin Lymphoma (NHL): Non-Hodgkin Lymphoma (NHL) is a cancer of the lymphatic system, responsible for circulating lymph, a fluid containing white blood cells that combat infections. NHL develops within lymphocytes, a type of white blood cell, and tends to affect adults more frequently than children. The disease encompasses various subtypes, with diffuse large B-cell lymphoma and follicular lymphoma being the most prevalent.

Multiple Myeloma (MM): Multiple Myeloma (MM) is a rare type of blood cancer originating in plasma cells, essential components of the immune system responsible for producing antibodies to fight infections. Although relatively uncommon, with a risk of 1 in 132 in the US, MM can have severe consequences. In MM, abnormal plasma cells proliferate uncontrollably, leading to the overcrowding of healthy blood cells. Moreover, these abnormal cells produce harmful proteins that accumulate in bones and blood, causing damage to organs throughout the body.

Expanding Treatment Options

Zion Medic offers CAR-T cell therapy for a diverse range of hematologic malignancies, including ALL, AML, NHL, and MM. Our comprehensive approach to cancer treatment involves tailored care plans designed to meet each patient’s individual needs, ensuring the best possible outcomes and quality of life. Reach out to us today to explore the potential of CAR-T therapy and embark on your journey toward overcoming cancer.

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